rs4757144
Variant in the BMAL1 gene (Basic Helix-Loop-Helix ARNT Like 1)
rs4757144 is a single nucleotide polymorphism (SNP) in the BMAL1 gene, involved in circadian clock. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4757144 variant?
rs4757144 is a SNP (single nucleotide polymorphism) in the BMAL1 (Basic Helix-Loop-Helix ARNT Like 1) gene. It belongs to the Circadian Rhythm category and is part of the Neurological & Sleep biological cluster. BMAL1 (ARNTL) is the non-redundant core clock component whose heterodimer with CLOCK drives transcription of PER and CRY genes. BMAL1 knockout mice show dramatically accelerated aging and metabolic dysfunction.
Biological role and pathway
This variant sits within the BMAL1 gene, which is involved in the circadian clock pathway. Genes within the Neurological & Sleep cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4757144 and Long COVID / ME-CFS research
BMAL1 controls rhythmic expression of immune genes including cytokines and pattern recognition receptors. Variants in BMAL1 may impair immune circadian organization, contributing to sustained inflammatory states in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: BMAL1
rs4757144 is one of 3 known variants in the BMAL1 gene. To understand the full biological context of this variant, explore the parent gene page.
View BMAL1 gene page →Conditions studied in relation to rs4757144
Research into BMAL1 variants including rs4757144 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include BMAL1 and the rs4757144 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the BMAL1 gene
The following variants in BMAL1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4757144 variant in the BMAL1 gene?
rs4757144 is a single nucleotide polymorphism (SNP) located in the BMAL1 (Basic Helix-Loop-Helix ARNT Like 1) gene, which is involved in circadian clock. BMAL1 (ARNTL) is the non-redundant core clock component whose heterodimer with CLOCK drives transcription of PER and CRY genes. BMAL1 knockout mice show dramatically accelerated aging and metabolic dysfunction.
How may the rs4757144 variant relate to Long COVID or ME/CFS?
BMAL1 controls rhythmic expression of immune genes including cytokines and pattern recognition receptors. Variants in BMAL1 may impair immune circadian organization, contributing to sustained inflammatory states in Long COVID.
Can a consumer DNA test detect the rs4757144 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4757144 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for BMAL1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 26752651
- [2]Cell Metabolism
- [3]Nature Immunology