rs6490997

What is the rs6490997 variant?

rs6490997 is a SNP (single nucleotide polymorphism) in the KAT6A (Lysine Acetyltransferase 6A) gene. It belongs to the Epigenetics category and is part of the Methylation & Neurotransmitters biological cluster. KAT6A encodes MOZ, a histone acetyltransferase that acetylates H3K23 and regulates developmental gene expression.

Biological role and pathway

This variant sits within the KAT6A gene, which is involved in the histone H3K23 acetylation / chromatin remodeling pathway. Genes within the Methylation & Neurotransmitters cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: KAT6A

rs6490997 is one of 1 known variant in the KAT6A gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs6490997

Research into KAT6A variants including rs6490997 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include KAT6A and the rs6490997 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions