rs1139985
Variant in the BST2 gene (Bone Marrow Stromal Cell Antigen 2)
rs1139985 is a single nucleotide polymorphism (SNP) in the BST2 gene, involved in antiviral restriction. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1139985 variant?
rs1139985 is a SNP (single nucleotide polymorphism) in the BST2 (Bone Marrow Stromal Cell Antigen 2) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. BST2 (tetherin/CD317) is an interferon-induced restriction factor that traps nascent virus particles at the cell surface, preventing their release. It is an ISG antagonized by HIV Vpu and other viral proteins.
Biological role and pathway
This variant sits within the BST2 gene, which is involved in the antiviral restriction pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1139985 and Long COVID / ME-CFS research
BST2 restricts SARS-CoV-2 release and its expression is induced by interferon in respiratory epithelium. Variants affecting BST2-mediated viral tethering may influence SARS-CoV-2 spread and the viral burden that predisposes to Long COVID development.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: BST2
rs1139985 is one of 3 known variants in the BST2 gene. To understand the full biological context of this variant, explore the parent gene page.
View BST2 gene page →Conditions studied in relation to rs1139985
Research into BST2 variants including rs1139985 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include BST2 and the rs1139985 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the BST2 gene
The following variants in BST2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1139985 variant in the BST2 gene?
rs1139985 is a single nucleotide polymorphism (SNP) located in the BST2 (Bone Marrow Stromal Cell Antigen 2) gene, which is involved in antiviral restriction. BST2 (tetherin/CD317) is an interferon-induced restriction factor that traps nascent virus particles at the cell surface, preventing their release. It is an ISG antagonized by HIV Vpu and other viral proteins.
How may the rs1139985 variant relate to Long COVID or ME/CFS?
BST2 restricts SARS-CoV-2 release and its expression is induced by interferon in respiratory epithelium. Variants affecting BST2-mediated viral tethering may influence SARS-CoV-2 spread and the viral burden that predisposes to Long COVID development.
Can a consumer DNA test detect the rs1139985 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1139985 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for BST2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 23239961
- [2]Nature
- [3]Cell Host & Microbe