rs13306575
Variant in the BTK gene (Bruton Tyrosine Kinase)
rs13306575 is a single nucleotide polymorphism (SNP) in the BTK gene, involved in B cell signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs13306575 variant?
rs13306575 is a SNP (single nucleotide polymorphism) in the BTK (Bruton Tyrosine Kinase) gene. It belongs to the Adaptive Immunity category and is part of the Adaptive Immunity biological cluster. BTK is a non-receptor tyrosine kinase essential for B cell receptor signal transduction and mast cell/macrophage activation. It is a therapeutic target for B cell malignancies and autoimmune diseases (ibrutinib).
Biological role and pathway
This variant sits within the BTK gene, which is involved in the B cell signaling pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs13306575 and Long COVID / ME-CFS research
BTK inhibition is being evaluated for COVID-19 cytokine storm management. Variants affecting BTK activity may alter B cell activation intensity and the production of pathogenic autoantibodies characterizing some Long COVID patients.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: BTK
rs13306575 is one of 3 known variants in the BTK gene. To understand the full biological context of this variant, explore the parent gene page.
View BTK gene page →Conditions studied in relation to rs13306575
Research into BTK variants including rs13306575 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include BTK and the rs13306575 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the BTK gene
The following variants in BTK are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs13306575 variant in the BTK gene?
rs13306575 is a single nucleotide polymorphism (SNP) located in the BTK (Bruton Tyrosine Kinase) gene, which is involved in B cell signaling. BTK is a non-receptor tyrosine kinase essential for B cell receptor signal transduction and mast cell/macrophage activation. It is a therapeutic target for B cell malignancies and autoimmune diseases (ibrutinib).
How may the rs13306575 variant relate to Long COVID or ME/CFS?
BTK inhibition is being evaluated for COVID-19 cytokine storm management. Variants affecting BTK activity may alter B cell activation intensity and the production of pathogenic autoantibodies characterizing some Long COVID patients.
Can a consumer DNA test detect the rs13306575 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs13306575 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for BTK and its variants. This is not an exhaustive literature review.
- [1]PMID: 33034286
- [2]Blood
- [3]Nature Reviews Immunology