rs1047286
Variant in the C3 gene (Complement C3)
rs1047286 is a single nucleotide polymorphism (SNP) in the C3 gene, involved in complement activation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1047286 variant?
rs1047286 is a SNP (single nucleotide polymorphism) in the C3 (Complement C3) gene. It belongs to the Complement category and is part of the Complement System biological cluster. C3 encodes complement component 3, the central protein of the complement cascade, which is cleaved to produce C3a and C3b mediators.
Biological role and pathway
This variant sits within the C3 gene, which is involved in the complement activation pathway. Genes within the Complement System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1047286 and Long COVID / ME-CFS research
Complement activation and C3 deposition have been observed in COVID-19 tissue injury and may contribute to persistent vascular and neural inflammation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: C3
rs1047286 is one of 2 known variants in the C3 gene. To understand the full biological context of this variant, explore the parent gene page.
View C3 gene page →Conditions studied in relation to rs1047286
Research into C3 variants including rs1047286 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include C3 and the rs1047286 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the C3 gene
The following variants in C3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1047286 variant in the C3 gene?
rs1047286 is a single nucleotide polymorphism (SNP) located in the C3 (Complement C3) gene, which is involved in complement activation. C3 encodes complement component 3, the central protein of the complement cascade, which is cleaved to produce C3a and C3b mediators.
How may the rs1047286 variant relate to Long COVID or ME/CFS?
Complement activation and C3 deposition have been observed in COVID-19 tissue injury and may contribute to persistent vascular and neural inflammation in Long COVID.
Can a consumer DNA test detect the rs1047286 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1047286 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for C3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Journal of Clinical Investigation