rs10754596

What is the rs10754596 variant?

rs10754596 is a SNP (single nucleotide polymorphism) in the C5AR1 (Complement C5a Receptor 1) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. C5AR1 encodes the C5a receptor, mediating the pro-inflammatory effects of C5a on neutrophils, macrophages, and endothelial cells.

Biological role and pathway

This variant sits within the C5AR1 gene, which is involved in the C5a anaphylatoxin signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: C5AR1

rs10754596 is one of 1 known variant in the C5AR1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs10754596

Research into C5AR1 variants including rs10754596 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include C5AR1 and the rs10754596 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions