rs1006737
Variant in the CACNA1C gene (Calcium Voltage-Gated Channel Subunit Alpha1 C)
rs1006737 is a single nucleotide polymorphism (SNP) in the CACNA1C gene, involved in L-type calcium channel / cardiac and neuronal signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1006737 variant?
rs1006737 is a SNP (single nucleotide polymorphism) in the CACNA1C (Calcium Voltage-Gated Channel Subunit Alpha1 C) gene. It belongs to the Cardiovascular category and is part of the Autonomic Nervous System biological cluster. CACNA1C encodes the alpha-1C subunit of the cardiac L-type calcium channel (Cav1.2), essential for cardiac excitation-contraction coupling and neuronal signaling.
Biological role and pathway
This variant sits within the CACNA1C gene, which is involved in the L-type calcium channel / cardiac and neuronal signaling pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1006737 and Long COVID / ME-CFS research
CACNA1C variants (rs1006737) are strongly associated with psychiatric disorders; calcium channel dysregulation may contribute to neuropsychiatric symptoms, mood disorders, and cardiac dysfunction in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CACNA1C
rs1006737 is one of 2 known variants in the CACNA1C gene. To understand the full biological context of this variant, explore the parent gene page.
View CACNA1C gene page →Conditions studied in relation to rs1006737
Research into CACNA1C variants including rs1006737 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CACNA1C and the rs1006737 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CACNA1C gene
The following variants in CACNA1C are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1006737 variant in the CACNA1C gene?
rs1006737 is a single nucleotide polymorphism (SNP) located in the CACNA1C (Calcium Voltage-Gated Channel Subunit Alpha1 C) gene, which is involved in L-type calcium channel / cardiac and neuronal signaling. CACNA1C encodes the alpha-1C subunit of the cardiac L-type calcium channel (Cav1.2), essential for cardiac excitation-contraction coupling and neuronal signaling.
How may the rs1006737 variant relate to Long COVID or ME/CFS?
CACNA1C variants (rs1006737) are strongly associated with psychiatric disorders; calcium channel dysregulation may contribute to neuropsychiatric symptoms, mood disorders, and cardiac dysfunction in Long COVID.
Can a consumer DNA test detect the rs1006737 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1006737 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CACNA1C and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Molecular Psychiatry