rs2290163
Variant in the CACNA1H gene (Calcium Voltage-Gated Channel Subunit Alpha1 H)
rs2290163 is a single nucleotide polymorphism (SNP) in the CACNA1H gene, involved in T-type calcium channel / pain and thalamic signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2290163 variant?
rs2290163 is a SNP (single nucleotide polymorphism) in the CACNA1H (Calcium Voltage-Gated Channel Subunit Alpha1 H) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. CACNA1H encodes Cav3.2, a T-type calcium channel involved in thalamic oscillations, pain sensitization, and neuronal excitability.
Biological role and pathway
This variant sits within the CACNA1H gene, which is involved in the T-type calcium channel / pain and thalamic signaling pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2290163 and Long COVID / ME-CFS research
T-type calcium channels contribute to central sensitization and pain processing; CACNA1H variants may affect pain hypersensitivity and the neurological symptoms of Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CACNA1H
rs2290163 is one of 1 known variant in the CACNA1H gene. To understand the full biological context of this variant, explore the parent gene page.
View CACNA1H gene page →Conditions studied in relation to rs2290163
Research into CACNA1H variants including rs2290163 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CACNA1H and the rs2290163 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs2290163 variant in the CACNA1H gene?
rs2290163 is a single nucleotide polymorphism (SNP) located in the CACNA1H (Calcium Voltage-Gated Channel Subunit Alpha1 H) gene, which is involved in T-type calcium channel / pain and thalamic signaling. CACNA1H encodes Cav3.2, a T-type calcium channel involved in thalamic oscillations, pain sensitization, and neuronal excitability.
How may the rs2290163 variant relate to Long COVID or ME/CFS?
T-type calcium channels contribute to central sensitization and pain processing; CACNA1H variants may affect pain hypersensitivity and the neurological symptoms of Long COVID.
Can a consumer DNA test detect the rs2290163 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2290163 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CACNA1H and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Nature Neuroscience