rs3809095

What is the rs3809095 variant?

rs3809095 is a SNP (single nucleotide polymorphism) in the CASP4 (Caspase 4 (Non-Canonical Inflammasome)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. CASP4 (human) and CASP11 (mouse) sense cytosolic LPS as part of the non-canonical inflammasome, activating GSDMD.

Biological role and pathway

This variant sits within the CASP4 gene, which is involved in the non-canonical inflammasome / LPS sensing pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: CASP4

rs3809095 is one of 1 known variant in the CASP4 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs3809095

Research into CASP4 variants including rs3809095 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CASP4 and the rs3809095 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions