rs4957149
Variant in the CAMP gene (Cathelicidin Antimicrobial Peptide (LL-37))
rs4957149 is a single nucleotide polymorphism (SNP) in the CAMP gene, involved in vitamin D-induced antimicrobial defense. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4957149 variant?
rs4957149 is a SNP (single nucleotide polymorphism) in the CAMP (Cathelicidin Antimicrobial Peptide (LL-37)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. CAMP encodes cathelicidin (LL-37), a vitamin D-induced antimicrobial peptide with broad-spectrum activity against bacteria, viruses, and fungi.
Biological role and pathway
This variant sits within the CAMP gene, which is involved in the vitamin D-induced antimicrobial defense pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4957149 and Long COVID / ME-CFS research
Vitamin D-induced cathelicidin (LL-37) has antiviral activity against enveloped viruses; low vitamin D in Long COVID patients may impair this first-line antimicrobial defense.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CAMP
rs4957149 is one of 1 known variant in the CAMP gene. To understand the full biological context of this variant, explore the parent gene page.
View CAMP gene page →Conditions studied in relation to rs4957149
Research into CAMP variants including rs4957149 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CAMP and the rs4957149 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs4957149 variant in the CAMP gene?
rs4957149 is a single nucleotide polymorphism (SNP) located in the CAMP (Cathelicidin Antimicrobial Peptide (LL-37)) gene, which is involved in vitamin D-induced antimicrobial defense. CAMP encodes cathelicidin (LL-37), a vitamin D-induced antimicrobial peptide with broad-spectrum activity against bacteria, viruses, and fungi.
How may the rs4957149 variant relate to Long COVID or ME/CFS?
Vitamin D-induced cathelicidin (LL-37) has antiviral activity against enveloped viruses; low vitamin D in Long COVID patients may impair this first-line antimicrobial defense.
Can a consumer DNA test detect the rs4957149 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4957149 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CAMP and its variants. This is not an exhaustive literature review.
- [1]PMID: 33387997
- [2]Journal of Immunology
- [3]Nature Immunology