rs2857656
Variant in the CCL2 gene (C-C Motif Chemokine Ligand 2)
rs2857656 is a single nucleotide polymorphism (SNP) in the CCL2 gene, involved in monocyte recruitment. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2857656 variant?
rs2857656 is a SNP (single nucleotide polymorphism) in the CCL2 (C-C Motif Chemokine Ligand 2) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. CCL2 (MCP-1) is the primary chemokine for monocyte and dendritic cell recruitment through CCR2. It is produced by endothelial cells, macrophages, and fibroblasts and is a key mediator of inflammatory monocyte infiltration.
Biological role and pathway
This variant sits within the CCL2 gene, which is involved in the monocyte recruitment pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2857656 and Long COVID / ME-CFS research
CCL2 is elevated in COVID-19 cytokine storms and drives monocyte-derived macrophage infiltration into lungs and other tissues. Elevated CCL2 in Long COVID may sustain monocyte/macrophage-driven inflammation and tissue damage relevant to persistent symptoms.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CCL2
rs2857656 is one of 3 known variants in the CCL2 gene. To understand the full biological context of this variant, explore the parent gene page.
View CCL2 gene page →Conditions studied in relation to rs2857656
Research into CCL2 variants including rs2857656 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CCL2 and the rs2857656 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CCL2 gene
The following variants in CCL2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2857656 variant in the CCL2 gene?
rs2857656 is a single nucleotide polymorphism (SNP) located in the CCL2 (C-C Motif Chemokine Ligand 2) gene, which is involved in monocyte recruitment. CCL2 (MCP-1) is the primary chemokine for monocyte and dendritic cell recruitment through CCR2. It is produced by endothelial cells, macrophages, and fibroblasts and is a key mediator of inflammatory monocyte infiltration.
How may the rs2857656 variant relate to Long COVID or ME/CFS?
CCL2 is elevated in COVID-19 cytokine storms and drives monocyte-derived macrophage infiltration into lungs and other tissues. Elevated CCL2 in Long COVID may sustain monocyte/macrophage-driven inflammation and tissue damage relevant to persistent symptoms.
Can a consumer DNA test detect the rs2857656 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2857656 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CCL2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32898910
- [2]Nature
- [3]Journal of Clinical Investigation