rs2107538
Variant in the CCL5 gene (C-C Motif Chemokine Ligand 5)
rs2107538 is a single nucleotide polymorphism (SNP) in the CCL5 gene, involved in immune cell chemotaxis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2107538 variant?
rs2107538 is a SNP (single nucleotide polymorphism) in the CCL5 (C-C Motif Chemokine Ligand 5) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. CCL5 (RANTES) recruits T cells, NK cells, monocytes, and eosinophils through CCR1, CCR3, and CCR5. It is stored in platelet alpha-granules and released upon activation, linking coagulation to immune recruitment.
Biological role and pathway
This variant sits within the CCL5 gene, which is involved in the immune cell chemotaxis pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2107538 and Long COVID / ME-CFS research
CCL5 is persistently elevated in Long COVID, and the CCL5-CCR5 axis is a proposed mechanism for ongoing T cell recruitment to inflamed tissues. CCL5 variants (including the 3p-deletion WHIM syndrome allele) affect chemokine availability relevant to immune persistence in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CCL5
rs2107538 is one of 3 known variants in the CCL5 gene. To understand the full biological context of this variant, explore the parent gene page.
View CCL5 gene page →Conditions studied in relation to rs2107538
Research into CCL5 variants including rs2107538 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CCL5 and the rs2107538 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CCL5 gene
The following variants in CCL5 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2107538 variant in the CCL5 gene?
rs2107538 is a single nucleotide polymorphism (SNP) located in the CCL5 (C-C Motif Chemokine Ligand 5) gene, which is involved in immune cell chemotaxis. CCL5 (RANTES) recruits T cells, NK cells, monocytes, and eosinophils through CCR1, CCR3, and CCR5. It is stored in platelet alpha-granules and released upon activation, linking coagulation to immune recruitment.
How may the rs2107538 variant relate to Long COVID or ME/CFS?
CCL5 is persistently elevated in Long COVID, and the CCL5-CCR5 axis is a proposed mechanism for ongoing T cell recruitment to inflamed tissues. CCL5 variants (including the 3p-deletion WHIM syndrome allele) affect chemokine availability relevant to immune persistence in Long COVID.
Can a consumer DNA test detect the rs2107538 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2107538 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CCL5 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33727702
- [2]Cell
- [3]Nature Immunology