rs1799987
Variant in the CCR5 gene (C-C Motif Chemokine Receptor 5)
rs1799987 is a single nucleotide polymorphism (SNP) in the CCR5 gene, involved in immune cell trafficking. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1799987 variant?
rs1799987 is a SNP (single nucleotide polymorphism) in the CCR5 (C-C Motif Chemokine Receptor 5) gene. It belongs to the Adaptive Immunity category and is part of the Adaptive Immunity biological cluster. CCR5 is the receptor for CCL3, CCL4, and CCL5 on T cells, macrophages, and NK cells. The 32-bp deletion (CCR5-Δ32) truncates the receptor and confers near-complete resistance to CCR5-tropic HIV-1 infection.
Biological role and pathway
This variant sits within the CCR5 gene, which is involved in the immune cell trafficking pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1799987 and Long COVID / ME-CFS research
CCR5-Δ32 homozygosity may influence COVID-19 susceptibility and Long COVID through altered T cell trafficking. CCR5 blockade (maraviroc) is being investigated for Long COVID, with the rationale of disrupting the CCL5-CCR5 driven immune infiltration.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CCR5
rs1799987 is one of 3 known variants in the CCR5 gene. To understand the full biological context of this variant, explore the parent gene page.
View CCR5 gene page →Conditions studied in relation to rs1799987
Research into CCR5 variants including rs1799987 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CCR5 and the rs1799987 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CCR5 gene
The following variants in CCR5 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1799987 variant in the CCR5 gene?
rs1799987 is a single nucleotide polymorphism (SNP) located in the CCR5 (C-C Motif Chemokine Receptor 5) gene, which is involved in immune cell trafficking. CCR5 is the receptor for CCL3, CCL4, and CCL5 on T cells, macrophages, and NK cells. The 32-bp deletion (CCR5-Δ32) truncates the receptor and confers near-complete resistance to CCR5-tropic HIV-1 infection.
How may the rs1799987 variant relate to Long COVID or ME/CFS?
CCR5-Δ32 homozygosity may influence COVID-19 susceptibility and Long COVID through altered T cell trafficking. CCR5 blockade (maraviroc) is being investigated for Long COVID, with the rationale of disrupting the CCL5-CCR5 driven immune infiltration.
Can a consumer DNA test detect the rs1799987 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1799987 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CCR5 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33727702
- [2]New England Journal of Medicine
- [3]Nature