rs4795392
Variant in the CD19 gene (CD19 Molecule)
rs4795392 is a single nucleotide polymorphism (SNP) in the CD19 gene, involved in B cell signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4795392 variant?
rs4795392 is a SNP (single nucleotide polymorphism) in the CD19 (CD19 Molecule) gene. It belongs to the Adaptive Immunity category and is part of the Adaptive Immunity biological cluster. CD19 is a co-receptor that amplifies B cell receptor signaling in complex with CD21 and CD81. It is a major regulator of B cell activation thresholds and a target of therapies for B cell malignancies and autoimmune diseases.
Biological role and pathway
This variant sits within the CD19 gene, which is involved in the B cell signaling pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4795392 and Long COVID / ME-CFS research
B cell hyperactivation and autoantibody production characterize Long COVID. CD19 variants affecting B cell activation thresholds may modulate susceptibility to autoimmune B cell responses. Low CD19+ B cells have been reported in some Long COVID patients.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CD19
rs4795392 is one of 3 known variants in the CD19 gene. To understand the full biological context of this variant, explore the parent gene page.
View CD19 gene page →Conditions studied in relation to rs4795392
Research into CD19 variants including rs4795392 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CD19 and the rs4795392 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CD19 gene
The following variants in CD19 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4795392 variant in the CD19 gene?
rs4795392 is a single nucleotide polymorphism (SNP) located in the CD19 (CD19 Molecule) gene, which is involved in B cell signaling. CD19 is a co-receptor that amplifies B cell receptor signaling in complex with CD21 and CD81. It is a major regulator of B cell activation thresholds and a target of therapies for B cell malignancies and autoimmune diseases.
How may the rs4795392 variant relate to Long COVID or ME/CFS?
B cell hyperactivation and autoantibody production characterize Long COVID. CD19 variants affecting B cell activation thresholds may modulate susceptibility to autoimmune B cell responses. Low CD19+ B cells have been reported in some Long COVID patients.
Can a consumer DNA test detect the rs4795392 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4795392 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CD19 and its variants. This is not an exhaustive literature review.
- [1]PMID: 30723090
- [2]Nature Immunology
- [3]Journal of Experimental Medicine