rs1130169
Variant in the CD38 gene (CD38 Molecule)
rs1130169 is a single nucleotide polymorphism (SNP) in the CD38 gene, involved in NAD+ consumption. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1130169 variant?
rs1130169 is a SNP (single nucleotide polymorphism) in the CD38 (CD38 Molecule) gene. It belongs to the Metabolism category and is part of the Mitochondrial & Metabolic biological cluster. CD38 is an ectoenzyme and receptor that consumes NAD+ to produce cyclic ADP-ribose and ADPR as calcium-mobilizing second messengers. It plays roles in immune cell activation, calcium signaling, and oxytocin metabolism.
Biological role and pathway
This variant sits within the CD38 gene, which is involved in the NAD+ consumption pathway. Genes within the Mitochondrial & Metabolic cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1130169 and Long COVID / ME-CFS research
CD38 overexpression can deplete NAD+ stores, exacerbating mitochondrial dysfunction. In Long COVID, heightened immune activation may drive CD38 upregulation, contributing to NAD+ deficiency and the energy-depletion phenotype of post-COVID fatigue.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CD38
rs1130169 is one of 3 known variants in the CD38 gene. To understand the full biological context of this variant, explore the parent gene page.
View CD38 gene page →Conditions studied in relation to rs1130169
Research into CD38 variants including rs1130169 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CD38 and the rs1130169 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CD38 gene
The following variants in CD38 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1130169 variant in the CD38 gene?
rs1130169 is a single nucleotide polymorphism (SNP) located in the CD38 (CD38 Molecule) gene, which is involved in NAD+ consumption. CD38 is an ectoenzyme and receptor that consumes NAD+ to produce cyclic ADP-ribose and ADPR as calcium-mobilizing second messengers. It plays roles in immune cell activation, calcium signaling, and oxytocin metabolism.
How may the rs1130169 variant relate to Long COVID or ME/CFS?
CD38 overexpression can deplete NAD+ stores, exacerbating mitochondrial dysfunction. In Long COVID, heightened immune activation may drive CD38 upregulation, contributing to NAD+ deficiency and the energy-depletion phenotype of post-COVID fatigue.
Can a consumer DNA test detect the rs1130169 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1130169 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CD38 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34556878
- [2]Nature Aging
- [3]Cell Reports