rs2395471

What is the rs2395471 variant?

rs2395471 is a SNP (single nucleotide polymorphism) in the CD4 (CD4 Molecule) gene. It belongs to the Lymphocyte category and is part of the Lymphocyte Biology biological cluster. CD4 encodes the co-receptor for MHC class II, expressed on helper T cells and macrophages; also serves as a SARS-CoV-2 entry receptor.

Biological role and pathway

This variant sits within the CD4 gene, which is involved in the MHC class II T cell signaling pathway. Genes within the Lymphocyte Biology cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: CD4

rs2395471 is one of 1 known variant in the CD4 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2395471

Research into CD4 variants including rs2395471 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CD4 and the rs2395471 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions