rs1535045
Variant in the CD40 gene (CD40 Molecule)
rs1535045 is a single nucleotide polymorphism (SNP) in the CD40 gene, involved in B cell activation / antigen presentation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1535045 variant?
rs1535045 is a SNP (single nucleotide polymorphism) in the CD40 (CD40 Molecule) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. CD40 encodes a TNF receptor family member on B cells and antigen-presenting cells that mediates CD40L-driven activation and class switching.
Biological role and pathway
This variant sits within the CD40 gene, which is involved in the B cell activation / antigen presentation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1535045 and Long COVID / ME-CFS research
CD40 signaling drives B cell activation and antibody class switching; variants may affect antibody responses to SARS-CoV-2 and autoantibody production in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CD40
rs1535045 is one of 2 known variants in the CD40 gene. To understand the full biological context of this variant, explore the parent gene page.
View CD40 gene page →Conditions studied in relation to rs1535045
Research into CD40 variants including rs1535045 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CD40 and the rs1535045 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CD40 gene
The following variants in CD40 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1535045 variant in the CD40 gene?
rs1535045 is a single nucleotide polymorphism (SNP) located in the CD40 (CD40 Molecule) gene, which is involved in B cell activation / antigen presentation. CD40 encodes a TNF receptor family member on B cells and antigen-presenting cells that mediates CD40L-driven activation and class switching.
How may the rs1535045 variant relate to Long COVID or ME/CFS?
CD40 signaling drives B cell activation and antibody class switching; variants may affect antibody responses to SARS-CoV-2 and autoantibody production in Long COVID.
Can a consumer DNA test detect the rs1535045 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1535045 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CD40 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Immunology
- [3]Journal of Experimental Medicine