rs1126535
Variant in the CD40LG gene (CD40 Ligand)
rs1126535 is a single nucleotide polymorphism (SNP) in the CD40LG gene, involved in B-T cell co-stimulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1126535 variant?
rs1126535 is a SNP (single nucleotide polymorphism) in the CD40LG (CD40 Ligand) gene. It belongs to the Lymphocyte category and is part of the Lymphocyte Biology biological cluster. CD40LG encodes CD40L (CD154), expressed on activated T helper cells, which engages CD40 on B cells to drive antibody class switching.
Biological role and pathway
This variant sits within the CD40LG gene, which is involved in the B-T cell co-stimulation pathway. Genes within the Lymphocyte Biology cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1126535 and Long COVID / ME-CFS research
CD40L-CD40 signaling drives humoral immunity and may be relevant to autoantibody generation in Long COVID immune dysregulation.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CD40LG
rs1126535 is one of 2 known variants in the CD40LG gene. To understand the full biological context of this variant, explore the parent gene page.
View CD40LG gene page →Conditions studied in relation to rs1126535
Research into CD40LG variants including rs1126535 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CD40LG and the rs1126535 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CD40LG gene
The following variants in CD40LG are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1126535 variant in the CD40LG gene?
rs1126535 is a single nucleotide polymorphism (SNP) located in the CD40LG (CD40 Ligand) gene, which is involved in B-T cell co-stimulation. CD40LG encodes CD40L (CD154), expressed on activated T helper cells, which engages CD40 on B cells to drive antibody class switching.
How may the rs1126535 variant relate to Long COVID or ME/CFS?
CD40L-CD40 signaling drives humoral immunity and may be relevant to autoantibody generation in Long COVID immune dysregulation.
Can a consumer DNA test detect the rs1126535 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1126535 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CD40LG and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Journal of Clinical Investigation