rs3092945
Variant in the CD40LG gene (CD40 Ligand (CD154))
rs3092945 is a single nucleotide polymorphism (SNP) in the CD40LG gene, involved in T cell-B cell collaboration / humoral immunity. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3092945 variant?
rs3092945 is a SNP (single nucleotide polymorphism) in the CD40LG (CD40 Ligand (CD154)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. CD40LG encodes CD40L/CD154, expressed on activated CD4+ T cells and platelets, which activates B cells and other antigen-presenting cells.
Biological role and pathway
This variant sits within the CD40LG gene, which is involved in the T cell-B cell collaboration / humoral immunity pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3092945 and Long COVID / ME-CFS research
CD40L-CD40 interaction is essential for T-dependent antibody responses to SARS-CoV-2; CD40LG variants may affect the quality of humoral immune responses and autoantibody formation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CD40LG
rs3092945 is one of 1 known variant in the CD40LG gene. To understand the full biological context of this variant, explore the parent gene page.
View CD40LG gene page →Conditions studied in relation to rs3092945
Research into CD40LG variants including rs3092945 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CD40LG and the rs3092945 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs3092945 variant in the CD40LG gene?
rs3092945 is a single nucleotide polymorphism (SNP) located in the CD40LG (CD40 Ligand (CD154)) gene, which is involved in T cell-B cell collaboration / humoral immunity. CD40LG encodes CD40L/CD154, expressed on activated CD4+ T cells and platelets, which activates B cells and other antigen-presenting cells.
How may the rs3092945 variant relate to Long COVID or ME/CFS?
CD40L-CD40 interaction is essential for T-dependent antibody responses to SARS-CoV-2; CD40LG variants may affect the quality of humoral immune responses and autoantibody formation in Long COVID.
Can a consumer DNA test detect the rs3092945 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3092945 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CD40LG and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Immunology
- [3]NEJM