rs13347
Variant in the CD44 gene (CD44 Molecule (Homing Cell Adhesion Molecule))
rs13347 is a single nucleotide polymorphism (SNP) in the CD44 gene, involved in cell adhesion / hyaluronan signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs13347 variant?
rs13347 is a SNP (single nucleotide polymorphism) in the CD44 (CD44 Molecule (Homing Cell Adhesion Molecule)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. CD44 encodes a cell surface glycoprotein receptor for hyaluronan and osteopontin, involved in cell adhesion, migration, and leukocyte homing.
Biological role and pathway
This variant sits within the CD44 gene, which is involved in the cell adhesion / hyaluronan signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs13347 and Long COVID / ME-CFS research
CD44 is upregulated on activated T cells; variants may affect T cell activation, tissue homing, and the persistence of T cell responses in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CD44
rs13347 is one of 1 known variant in the CD44 gene. To understand the full biological context of this variant, explore the parent gene page.
View CD44 gene page →Conditions studied in relation to rs13347
Research into CD44 variants including rs13347 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CD44 and the rs13347 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs13347 variant in the CD44 gene?
rs13347 is a single nucleotide polymorphism (SNP) located in the CD44 (CD44 Molecule (Homing Cell Adhesion Molecule)) gene, which is involved in cell adhesion / hyaluronan signaling. CD44 encodes a cell surface glycoprotein receptor for hyaluronan and osteopontin, involved in cell adhesion, migration, and leukocyte homing.
How may the rs13347 variant relate to Long COVID or ME/CFS?
CD44 is upregulated on activated T cells; variants may affect T cell activation, tissue homing, and the persistence of T cell responses in Long COVID.
Can a consumer DNA test detect the rs13347 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs13347 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CD44 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Immunology
- [3]Journal of Immunology