rs62268385

What is the rs62268385 variant?

rs62268385 is a SNP (single nucleotide polymorphism) in the CD59 (CD59 Molecule (Protectin)) gene. It belongs to the Immune Signaling category and is part of the Coagulation & Microcirculation biological cluster. CD59 encodes protectin, a GPI-anchored membrane protein on erythrocytes and nucleated cells that inhibits MAC formation.

Biological role and pathway

This variant sits within the CD59 gene, which is involved in the terminal complement inhibition pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: CD59

rs62268385 is one of 1 known variant in the CD59 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs62268385

Research into CD59 variants including rs62268385 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CD59 and the rs62268385 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions