rs2256805

What is the rs2256805 variant?

rs2256805 is a SNP (single nucleotide polymorphism) in the CD8A (CD8 Alpha Chain) gene. It belongs to the Lymphocyte category and is part of the Lymphocyte Biology biological cluster. CD8A encodes the alpha chain of the CD8 co-receptor, expressed on cytotoxic T lymphocytes and NK T cells, co-signaling with TCR at MHC class I.

Biological role and pathway

This variant sits within the CD8A gene, which is involved in the MHC class I cytotoxic T cell signaling pathway. Genes within the Lymphocyte Biology cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: CD8A

rs2256805 is one of 1 known variant in the CD8A gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2256805

Research into CD8A variants including rs2256805 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CD8A and the rs2256805 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions