rs16260
Variant in the CDH1 gene (Cadherin 1 (E-Cadherin))
rs16260 is a single nucleotide polymorphism (SNP) in the CDH1 gene, involved in epithelial adherens junction / EMT suppressor. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs16260 variant?
rs16260 is a SNP (single nucleotide polymorphism) in the CDH1 (Cadherin 1 (E-Cadherin)) gene. It belongs to the Connective Tissue category and is part of the Coagulation & Microcirculation biological cluster. CDH1 encodes E-cadherin, the main epithelial adherens junction protein; its loss marks EMT.
Biological role and pathway
This variant sits within the CDH1 gene, which is involved in the epithelial adherens junction / EMT suppressor pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs16260 and Long COVID / ME-CFS research
E-cadherin maintenance is critical for epithelial barrier function; CDH1 downregulation by SNAI1 in COVID-19-infected epithelium may contribute to barrier dysfunction in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CDH1
rs16260 is one of 2 known variants in the CDH1 gene. To understand the full biological context of this variant, explore the parent gene page.
View CDH1 gene page →Conditions studied in relation to rs16260
Research into CDH1 variants including rs16260 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CDH1 and the rs16260 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CDH1 gene
The following variants in CDH1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs16260 variant in the CDH1 gene?
rs16260 is a single nucleotide polymorphism (SNP) located in the CDH1 (Cadherin 1 (E-Cadherin)) gene, which is involved in epithelial adherens junction / EMT suppressor. CDH1 encodes E-cadherin, the main epithelial adherens junction protein; its loss marks EMT.
How may the rs16260 variant relate to Long COVID or ME/CFS?
E-cadherin maintenance is critical for epithelial barrier function; CDH1 downregulation by SNAI1 in COVID-19-infected epithelium may contribute to barrier dysfunction in Long COVID.
Can a consumer DNA test detect the rs16260 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs16260 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CDH1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33141942
- [2]Nature Genetics
- [3]Cell