rs543322

What is the rs543322 variant?

rs543322 is a SNP (single nucleotide polymorphism) in the CHRM3 (Cholinergic Receptor Muscarinic 3) gene. It belongs to the Autonomic category and is part of the Autonomic Nervous System biological cluster. CHRM3 encodes the M3 muscarinic receptor on smooth muscle and secretory cells mediating bronchoconstriction and gland secretion.

Biological role and pathway

This variant sits within the CHRM3 gene, which is involved in the smooth muscle cholinergic signaling pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: CHRM3

rs543322 is one of 1 known variant in the CHRM3 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs543322

Research into CHRM3 variants including rs543322 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CHRM3 and the rs543322 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions