rs2302590
Variant in the CLDN1 gene (Claudin 1)
rs2302590 is a single nucleotide polymorphism (SNP) in the CLDN1 gene, involved in tight junction. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2302590 variant?
rs2302590 is a SNP (single nucleotide polymorphism) in the CLDN1 (Claudin 1) gene. It belongs to the Gut Barrier category and is part of the Gut-Brain Axis biological cluster. Claudin-1 is a tight junction transmembrane protein critical for paracellular barrier function in intestinal epithelium. It is also a co-receptor for hepatitis C virus entry.
Biological role and pathway
This variant sits within the CLDN1 gene, which is involved in the tight junction pathway. Genes within the Gut-Brain Axis cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2302590 and Long COVID / ME-CFS research
Claudin-1 expression is reduced in inflamed intestinal tissue. Variants affecting gut barrier integrity through CLDN1 may increase susceptibility to intestinal permeability and the translocation of microbial products driving systemic inflammation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CLDN1
rs2302590 is one of 2 known variants in the CLDN1 gene. To understand the full biological context of this variant, explore the parent gene page.
View CLDN1 gene page →Conditions studied in relation to rs2302590
Research into CLDN1 variants including rs2302590 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CLDN1 and the rs2302590 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CLDN1 gene
The following variants in CLDN1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2302590 variant in the CLDN1 gene?
rs2302590 is a single nucleotide polymorphism (SNP) located in the CLDN1 (Claudin 1) gene, which is involved in tight junction. Claudin-1 is a tight junction transmembrane protein critical for paracellular barrier function in intestinal epithelium. It is also a co-receptor for hepatitis C virus entry.
How may the rs2302590 variant relate to Long COVID or ME/CFS?
Claudin-1 expression is reduced in inflamed intestinal tissue. Variants affecting gut barrier integrity through CLDN1 may increase susceptibility to intestinal permeability and the translocation of microbial products driving systemic inflammation in Long COVID.
Can a consumer DNA test detect the rs2302590 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2302590 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CLDN1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 23548001
- [2]Gastroenterology
- [3]Cellular and Molecular Gastroenterology and Hepatology