rs16910526
Variant in the CLEC7A gene (C-Type Lectin Domain Family 7 Member A)
rs16910526 is a single nucleotide polymorphism (SNP) in the CLEC7A gene, involved in C-type lectin signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs16910526 variant?
rs16910526 is a SNP (single nucleotide polymorphism) in the CLEC7A (C-Type Lectin Domain Family 7 Member A) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. CLEC7A (Dectin-1) is the major pattern recognition receptor for beta-glucan in fungal cell walls. It signals through CARD9 to drive Th1/Th17 responses and is also involved in recognizing ligands on cancer cells and dead cells.
Biological role and pathway
This variant sits within the CLEC7A gene, which is involved in the C-type lectin signaling pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs16910526 and Long COVID / ME-CFS research
Dectin-1 rs16910526 (Y238X stop codon) causes Dectin-1 deficiency, predisposing to mucosal candidiasis. Aspergillus colonization complicates critical COVID-19, and CLEC7A variants may influence the fungal component of post-COVID immune challenges.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CLEC7A
rs16910526 is one of 2 known variants in the CLEC7A gene. To understand the full biological context of this variant, explore the parent gene page.
View CLEC7A gene page →Conditions studied in relation to rs16910526
Research into CLEC7A variants including rs16910526 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CLEC7A and the rs16910526 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CLEC7A gene
The following variants in CLEC7A are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs16910526 variant in the CLEC7A gene?
rs16910526 is a single nucleotide polymorphism (SNP) located in the CLEC7A (C-Type Lectin Domain Family 7 Member A) gene, which is involved in C-type lectin signaling. CLEC7A (Dectin-1) is the major pattern recognition receptor for beta-glucan in fungal cell walls. It signals through CARD9 to drive Th1/Th17 responses and is also involved in recognizing ligands on cancer cells and dead cells.
How may the rs16910526 variant relate to Long COVID or ME/CFS?
Dectin-1 rs16910526 (Y238X stop codon) causes Dectin-1 deficiency, predisposing to mucosal candidiasis. Aspergillus colonization complicates critical COVID-19, and CLEC7A variants may influence the fungal component of post-COVID immune challenges.
Can a consumer DNA test detect the rs16910526 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs16910526 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CLEC7A and its variants. This is not an exhaustive literature review.
- [1]PMID: 26829758
- [2]Nature Immunology
- [3]New England Journal of Medicine