rs1801260
Variant in the CLOCK gene (Clock Circadian Regulator)
rs1801260 is a single nucleotide polymorphism (SNP) in the CLOCK gene, involved in circadian clock. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1801260 variant?
rs1801260 is a SNP (single nucleotide polymorphism) in the CLOCK (Clock Circadian Regulator) gene. It belongs to the Circadian Rhythm category and is part of the Neurological & Sleep biological cluster. CLOCK is a transcription factor that forms heterodimers with BMAL1 to drive expression of circadian target genes including PER and CRY. It regulates rhythmic transcription across virtually all tissues.
Biological role and pathway
This variant sits within the CLOCK gene, which is involved in the circadian clock pathway. Genes within the Neurological & Sleep cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1801260 and Long COVID / ME-CFS research
CLOCK variants influence circadian period length, sleep timing, and metabolic rhythms. Disrupted CLOCK function may impair the circadian regulation of immune responses and tissue repair critical to Long COVID recovery.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CLOCK
rs1801260 is one of 3 known variants in the CLOCK gene. To understand the full biological context of this variant, explore the parent gene page.
View CLOCK gene page →Conditions studied in relation to rs1801260
Research into CLOCK variants including rs1801260 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CLOCK and the rs1801260 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CLOCK gene
The following variants in CLOCK are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1801260 variant in the CLOCK gene?
rs1801260 is a single nucleotide polymorphism (SNP) located in the CLOCK (Clock Circadian Regulator) gene, which is involved in circadian clock. CLOCK is a transcription factor that forms heterodimers with BMAL1 to drive expression of circadian target genes including PER and CRY. It regulates rhythmic transcription across virtually all tissues.
How may the rs1801260 variant relate to Long COVID or ME/CFS?
CLOCK variants influence circadian period length, sleep timing, and metabolic rhythms. Disrupted CLOCK function may impair the circadian regulation of immune responses and tissue repair critical to Long COVID recovery.
Can a consumer DNA test detect the rs1801260 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1801260 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CLOCK and its variants. This is not an exhaustive literature review.
- [1]PMID: 28877483
- [2]Science
- [3]Nature Genetics