rs1049353
Variant in the CNR1 gene (Cannabinoid Receptor 1)
rs1049353 is a single nucleotide polymorphism (SNP) in the CNR1 gene, involved in endocannabinoid signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1049353 variant?
rs1049353 is a SNP (single nucleotide polymorphism) in the CNR1 (Cannabinoid Receptor 1) gene. It belongs to the Pain Sensory category and is part of the Pain & Sensory Processing biological cluster. CNR1 encodes the CB1 cannabinoid receptor, which mediates analgesic, anxiolytic, and neuroprotective effects of endocannabinoids.
Biological role and pathway
This variant sits within the CNR1 gene, which is involved in the endocannabinoid signaling pathway. Genes within the Pain & Sensory Processing cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1049353 and Long COVID / ME-CFS research
CNR1 variants may influence endocannabinoid tone and modulate pain, anxiety, and neuroinflammation in Long COVID patients.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CNR1
rs1049353 is one of 2 known variants in the CNR1 gene. To understand the full biological context of this variant, explore the parent gene page.
View CNR1 gene page →Conditions studied in relation to rs1049353
Research into CNR1 variants including rs1049353 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CNR1 and the rs1049353 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CNR1 gene
The following variants in CNR1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1049353 variant in the CNR1 gene?
rs1049353 is a single nucleotide polymorphism (SNP) located in the CNR1 (Cannabinoid Receptor 1) gene, which is involved in endocannabinoid signaling. CNR1 encodes the CB1 cannabinoid receptor, which mediates analgesic, anxiolytic, and neuroprotective effects of endocannabinoids.
How may the rs1049353 variant relate to Long COVID or ME/CFS?
CNR1 variants may influence endocannabinoid tone and modulate pain, anxiety, and neuroinflammation in Long COVID patients.
Can a consumer DNA test detect the rs1049353 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1049353 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CNR1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32272069
- [2]Nature Genetics
- [3]Journal of Clinical Investigation