rs2229579
Variant in the CNR2 gene (Cannabinoid Receptor 2)
rs2229579 is a single nucleotide polymorphism (SNP) in the CNR2 gene, involved in endocannabinoid immune modulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2229579 variant?
rs2229579 is a SNP (single nucleotide polymorphism) in the CNR2 (Cannabinoid Receptor 2) gene. It belongs to the Immune Signaling category and is part of the Immune Regulation biological cluster. CNR2 encodes the CB2 cannabinoid receptor, predominantly expressed on immune cells, mediating anti-inflammatory effects of endocannabinoids.
Biological role and pathway
This variant sits within the CNR2 gene, which is involved in the endocannabinoid immune modulation pathway. Genes within the Immune Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2229579 and Long COVID / ME-CFS research
CNR2 activation has potent anti-inflammatory effects; variants may influence neuroinflammation and immune cell activation relevant to Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CNR2
rs2229579 is one of 2 known variants in the CNR2 gene. To understand the full biological context of this variant, explore the parent gene page.
View CNR2 gene page →Conditions studied in relation to rs2229579
Research into CNR2 variants including rs2229579 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CNR2 and the rs2229579 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CNR2 gene
The following variants in CNR2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2229579 variant in the CNR2 gene?
rs2229579 is a single nucleotide polymorphism (SNP) located in the CNR2 (Cannabinoid Receptor 2) gene, which is involved in endocannabinoid immune modulation. CNR2 encodes the CB2 cannabinoid receptor, predominantly expressed on immune cells, mediating anti-inflammatory effects of endocannabinoids.
How may the rs2229579 variant relate to Long COVID or ME/CFS?
CNR2 activation has potent anti-inflammatory effects; variants may influence neuroinflammation and immune cell activation relevant to Long COVID.
Can a consumer DNA test detect the rs2229579 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2229579 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CNR2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32272069
- [2]Nature Genetics
- [3]Journal of Clinical Investigation