rs2586488
Variant in the COL1A1 gene (Collagen Type I Alpha 1 Chain)
rs2586488 is a single nucleotide polymorphism (SNP) in the COL1A1 gene, involved in extracellular matrix / structural integrity. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2586488 variant?
rs2586488 is a SNP (single nucleotide polymorphism) in the COL1A1 (Collagen Type I Alpha 1 Chain) gene. It belongs to the Connective Tissue category and is part of the Coagulation & Microcirculation biological cluster. COL1A1 encodes the alpha-1 chain of type I collagen, the most abundant structural protein in connective tissue, bone, and skin.
Biological role and pathway
This variant sits within the COL1A1 gene, which is involved in the extracellular matrix / structural integrity pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2586488 and Long COVID / ME-CFS research
Post-COVID fibrotic changes in lung and other tissues involve collagen deposition; COL1A1 variants may affect the degree of fibrotic remodeling in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: COL1A1
rs2586488 is one of 2 known variants in the COL1A1 gene. To understand the full biological context of this variant, explore the parent gene page.
View COL1A1 gene page →Conditions studied in relation to rs2586488
Research into COL1A1 variants including rs2586488 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include COL1A1 and the rs2586488 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the COL1A1 gene
The following variants in COL1A1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2586488 variant in the COL1A1 gene?
rs2586488 is a single nucleotide polymorphism (SNP) located in the COL1A1 (Collagen Type I Alpha 1 Chain) gene, which is involved in extracellular matrix / structural integrity. COL1A1 encodes the alpha-1 chain of type I collagen, the most abundant structural protein in connective tissue, bone, and skin.
How may the rs2586488 variant relate to Long COVID or ME/CFS?
Post-COVID fibrotic changes in lung and other tissues involve collagen deposition; COL1A1 variants may affect the degree of fibrotic remodeling in Long COVID.
Can a consumer DNA test detect the rs2586488 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2586488 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for COL1A1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33141942
- [2]Nature Genetics
- [3]Journal of Bone and Mineral Research