rs1793953

What is the rs1793953 variant?

rs1793953 is a SNP (single nucleotide polymorphism) in the COL2A1 (Collagen Type II Alpha 1 Chain) gene. It belongs to the Connective Tissue category and is part of the Coagulation & Microcirculation biological cluster. COL2A1 encodes type II collagen, the major structural component of cartilage and vitreous body.

Biological role and pathway

This variant sits within the COL2A1 gene, which is involved in the cartilage ECM / structural integrity pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: COL2A1

rs1793953 is one of 1 known variant in the COL2A1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1793953

Research into COL2A1 variants including rs1793953 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include COL2A1 and the rs1793953 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions