rs1800255

What is the rs1800255 variant?

rs1800255 is a SNP (single nucleotide polymorphism) in the COL3A1 (Collagen Type III Alpha 1 Chain) gene. It belongs to the Connective Tissue category and is part of the Coagulation & Microcirculation biological cluster. COL3A1 encodes type III collagen, which is important for vascular and skin integrity.

Biological role and pathway

This variant sits within the COL3A1 gene, which is involved in the extracellular matrix / vascular integrity pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: COL3A1

rs1800255 is one of 1 known variant in the COL3A1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1800255

Research into COL3A1 variants including rs1800255 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include COL3A1 and the rs1800255 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions