rs35516535

What is the rs35516535 variant?

rs35516535 is a SNP (single nucleotide polymorphism) in the COL6A1 (Collagen Type VI Alpha 1 Chain) gene. It belongs to the Connective Tissue category and is part of the Connective Tissue & EDS biological cluster. COL6A1 encodes a component of type VI collagen microfibrils, which link the ECM to cells in various tissues including muscle.

Biological role and pathway

This variant sits within the COL6A1 gene, which is involved in the extracellular matrix formation pathway. Genes within the Connective Tissue & EDS cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: COL6A1

rs35516535 is one of 1 known variant in the COL6A1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs35516535

Research into COL6A1 variants including rs35516535 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include COL6A1 and the rs35516535 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the COL6A1 gene

The following variants in COL6A1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions