rs13401
Variant in the COX4I1 gene (Cytochrome C Oxidase Subunit 4I1)
rs13401 is a single nucleotide polymorphism (SNP) in the COX4I1 gene, involved in electron transport chain complex IV. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs13401 variant?
rs13401 is a SNP (single nucleotide polymorphism) in the COX4I1 (Cytochrome C Oxidase Subunit 4I1) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. COX4I1 encodes a nuclear-encoded subunit of complex IV (cytochrome c oxidase), the terminal enzyme of the mitochondrial electron transport chain.
Biological role and pathway
This variant sits within the COX4I1 gene, which is involved in the electron transport chain complex IV pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs13401 and Long COVID / ME-CFS research
Complex IV is the oxygen-consuming step of oxidative phosphorylation; variants may affect mitochondrial ATP synthesis and oxygen utilization, contributing to fatigue and exercise intolerance in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: COX4I1
rs13401 is one of 1 known variant in the COX4I1 gene. To understand the full biological context of this variant, explore the parent gene page.
View COX4I1 gene page →Conditions studied in relation to rs13401
Research into COX4I1 variants including rs13401 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include COX4I1 and the rs13401 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs13401 variant in the COX4I1 gene?
rs13401 is a single nucleotide polymorphism (SNP) located in the COX4I1 (Cytochrome C Oxidase Subunit 4I1) gene, which is involved in electron transport chain complex IV. COX4I1 encodes a nuclear-encoded subunit of complex IV (cytochrome c oxidase), the terminal enzyme of the mitochondrial electron transport chain.
How may the rs13401 variant relate to Long COVID or ME/CFS?
Complex IV is the oxygen-consuming step of oxidative phosphorylation; variants may affect mitochondrial ATP synthesis and oxygen utilization, contributing to fatigue and exercise intolerance in Long COVID.
Can a consumer DNA test detect the rs13401 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs13401 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for COX4I1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Biochimica et Biophysica Acta