rs7289261

Variant in the CPA3 gene (Carboxypeptidase A3)

rs7289261 is a single nucleotide polymorphism (SNP) in the CPA3 gene, involved in mast cell degranulation marker. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.

This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.

What is the rs7289261 variant?

rs7289261 is a SNP (single nucleotide polymorphism) in the CPA3 (Carboxypeptidase A3) gene. It belongs to the Immune Signaling category and is part of the Histamine & MCAS biological cluster. CPA3 encodes carboxypeptidase A3, a mast cell-specific serine protease released upon degranulation that is used as a mast cell biomarker.

Biological role and pathway

This variant sits within the CPA3 gene, which is involved in the mast cell degranulation marker pathway. Genes within the Histamine & MCAS cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

rs7289261 and Long COVID / ME-CFS research

CPA3 is a specific mast cell degranulation marker; elevated CPA3 levels in some Long COVID patients support mast cell activation syndrome, with CPA3 variants potentially affecting enzyme expression.

This information is based on published research and does not constitute medical advice. See references below.

Parent gene: CPA3

rs7289261 is one of 1 known variant in the CPA3 gene. To understand the full biological context of this variant, explore the parent gene page.

View CPA3 gene page →

Conditions studied in relation to rs7289261

Research into CPA3 variants including rs7289261 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Long Covid Mast Cell Activation Mcas

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CPA3 and the rs7289261 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions

What is the rs7289261 variant in the CPA3 gene?

rs7289261 is a single nucleotide polymorphism (SNP) located in the CPA3 (Carboxypeptidase A3) gene, which is involved in mast cell degranulation marker. CPA3 encodes carboxypeptidase A3, a mast cell-specific serine protease released upon degranulation that is used as a mast cell biomarker.

How may the rs7289261 variant relate to Long COVID or ME/CFS?

CPA3 is a specific mast cell degranulation marker; elevated CPA3 levels in some Long COVID patients support mast cell activation syndrome, with CPA3 variants potentially affecting enzyme expression.

Can a consumer DNA test detect the rs7289261 variant?

Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.

Long COVID MCAS: Mast Cells, Histamine and Your Genes
Learn how Long COVID MCAS may develop, how it overlaps with POTS and histamine intolerance, and which genes research links to mast cell activity.

Find out if you carry the rs7289261 variant

Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.

Get Your Personalised DNA Report

Informational and educational only · Not a diagnostic tool · GDPR compliant

References

The following publications were used in compiling the research context for CPA3 and its variants. This is not an exhaustive literature review.

[1]PMID: 33398161
[2]Nature Genetics
[3]Journal of Allergy and Clinical Immunology