rs80356779
Variant in the CPT1A gene (Carnitine Palmitoyltransferase 1A)
rs80356779 is a single nucleotide polymorphism (SNP) in the CPT1A gene, involved in fatty acid oxidation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs80356779 variant?
rs80356779 is a SNP (single nucleotide polymorphism) in the CPT1A (Carnitine Palmitoyltransferase 1A) gene. It belongs to the Mitochondrial category and is part of the Mitochondrial Energy Production & PEM biological cluster. CPT1A encodes carnitine palmitoyltransferase 1A, which facilitates transport of long-chain fatty acids into mitochondria for beta-oxidation.
Biological role and pathway
This variant sits within the CPT1A gene, which is involved in the fatty acid oxidation pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs80356779 and Long COVID / ME-CFS research
CPT1A-mediated fatty acid oxidation is the primary fuel source for many tissues; impaired CPT1A activity may contribute to energy deficits in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CPT1A
rs80356779 is one of 1 known variant in the CPT1A gene. To understand the full biological context of this variant, explore the parent gene page.
View CPT1A gene page →Conditions studied in relation to rs80356779
Research into CPT1A variants including rs80356779 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CPT1A and the rs80356779 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CPT1A gene
The following variants in CPT1A are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs80356779 variant in the CPT1A gene?
rs80356779 is a single nucleotide polymorphism (SNP) located in the CPT1A (Carnitine Palmitoyltransferase 1A) gene, which is involved in fatty acid oxidation. CPT1A encodes carnitine palmitoyltransferase 1A, which facilitates transport of long-chain fatty acids into mitochondria for beta-oxidation.
How may the rs80356779 variant relate to Long COVID or ME/CFS?
CPT1A-mediated fatty acid oxidation is the primary fuel source for many tissues; impaired CPT1A activity may contribute to energy deficits in Long COVID.
Can a consumer DNA test detect the rs80356779 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs80356779 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CPT1A and its variants. This is not an exhaustive literature review.
- [1]PMID: 32735956
- [2]Nature Genetics
- [3]Journal of Clinical Investigation