rs4844609
Variant in the CR1 gene (Complement C3b/C4b Receptor 1)
rs4844609 is a single nucleotide polymorphism (SNP) in the CR1 gene, involved in complement opsonization. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4844609 variant?
rs4844609 is a SNP (single nucleotide polymorphism) in the CR1 (Complement C3b/C4b Receptor 1) gene. It belongs to the Complement category and is part of the Complement System biological cluster. CR1 encodes complement receptor 1 (CD35), which binds C3b/C4b to facilitate phagocytosis and immune complex clearance.
Biological role and pathway
This variant sits within the CR1 gene, which is involved in the complement opsonization pathway. Genes within the Complement System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4844609 and Long COVID / ME-CFS research
CR1 variants affecting immune complex clearance may contribute to deposition of complement-coated debris and vascular inflammation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CR1
rs4844609 is one of 2 known variants in the CR1 gene. To understand the full biological context of this variant, explore the parent gene page.
View CR1 gene page →Conditions studied in relation to rs4844609
Research into CR1 variants including rs4844609 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CR1 and the rs4844609 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CR1 gene
The following variants in CR1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4844609 variant in the CR1 gene?
rs4844609 is a single nucleotide polymorphism (SNP) located in the CR1 (Complement C3b/C4b Receptor 1) gene, which is involved in complement opsonization. CR1 encodes complement receptor 1 (CD35), which binds C3b/C4b to facilitate phagocytosis and immune complex clearance.
How may the rs4844609 variant relate to Long COVID or ME/CFS?
CR1 variants affecting immune complex clearance may contribute to deposition of complement-coated debris and vascular inflammation in Long COVID.
Can a consumer DNA test detect the rs4844609 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4844609 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CR1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Journal of Clinical Investigation