rs6999235
Variant in the CRH gene (Corticotropin-Releasing Hormone)
rs6999235 is a single nucleotide polymorphism (SNP) in the CRH gene, involved in HPA axis initiation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs6999235 variant?
rs6999235 is a SNP (single nucleotide polymorphism) in the CRH (Corticotropin-Releasing Hormone) gene. It belongs to the Neuroendocrine category and is part of the Autonomic Nervous System biological cluster. CRH encodes corticotropin-releasing hormone, the hypothalamic neuropeptide that initiates the HPA stress axis by stimulating ACTH secretion.
Biological role and pathway
This variant sits within the CRH gene, which is involved in the HPA axis initiation pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs6999235 and Long COVID / ME-CFS research
HPA axis dysregulation with altered CRH-ACTH-cortisol dynamics is documented in Long COVID and ME/CFS; CRH variants may affect stress resilience and fatigue severity.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CRH
rs6999235 is one of 2 known variants in the CRH gene. To understand the full biological context of this variant, explore the parent gene page.
View CRH gene page →Conditions studied in relation to rs6999235
Research into CRH variants including rs6999235 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CRH and the rs6999235 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CRH gene
The following variants in CRH are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs6999235 variant in the CRH gene?
rs6999235 is a single nucleotide polymorphism (SNP) located in the CRH (Corticotropin-Releasing Hormone) gene, which is involved in HPA axis initiation. CRH encodes corticotropin-releasing hormone, the hypothalamic neuropeptide that initiates the HPA stress axis by stimulating ACTH secretion.
How may the rs6999235 variant relate to Long COVID or ME/CFS?
HPA axis dysregulation with altered CRH-ACTH-cortisol dynamics is documented in Long COVID and ME/CFS; CRH variants may affect stress resilience and fatigue severity.
Can a consumer DNA test detect the rs6999235 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs6999235 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CRH and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Reviews Neuroscience
- [3]Psychoneuroendocrinology