rs7123390
Variant in the CRY2 gene (Cryptochrome Circadian Regulator 2)
rs7123390 is a single nucleotide polymorphism (SNP) in the CRY2 gene, involved in circadian clock. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs7123390 variant?
rs7123390 is a SNP (single nucleotide polymorphism) in the CRY2 (Cryptochrome Circadian Regulator 2) gene. It belongs to the Circadian Rhythm category and is part of the Neurological & Sleep biological cluster. CRY2 encodes a second cryptochrome that represses CLOCK/BMAL1 transcription with CRY1. CRY2 has additional roles in DNA damage responses and metabolic regulation beyond circadian timekeeping.
Biological role and pathway
This variant sits within the CRY2 gene, which is involved in the circadian clock pathway. Genes within the Neurological & Sleep cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs7123390 and Long COVID / ME-CFS research
CRY2 polymorphisms are associated with depression and seasonal mood variation, conditions frequently comorbid with Long COVID. Circadian disruption affecting CRY2 function may compound the neuropsychiatric manifestations of post-COVID syndrome.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CRY2
rs7123390 is one of 2 known variants in the CRY2 gene. To understand the full biological context of this variant, explore the parent gene page.
View CRY2 gene page →Conditions studied in relation to rs7123390
Research into CRY2 variants including rs7123390 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CRY2 and the rs7123390 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CRY2 gene
The following variants in CRY2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs7123390 variant in the CRY2 gene?
rs7123390 is a single nucleotide polymorphism (SNP) located in the CRY2 (Cryptochrome Circadian Regulator 2) gene, which is involved in circadian clock. CRY2 encodes a second cryptochrome that represses CLOCK/BMAL1 transcription with CRY1. CRY2 has additional roles in DNA damage responses and metabolic regulation beyond circadian timekeeping.
How may the rs7123390 variant relate to Long COVID or ME/CFS?
CRY2 polymorphisms are associated with depression and seasonal mood variation, conditions frequently comorbid with Long COVID. Circadian disruption affecting CRY2 function may compound the neuropsychiatric manifestations of post-COVID syndrome.
Can a consumer DNA test detect the rs7123390 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs7123390 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CRY2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 27399967
- [2]Nature Genetics
- [3]Molecular Psychiatry