rs1005473

What is the rs1005473 variant?

rs1005473 is a SNP (single nucleotide polymorphism) in the CSNK1E (Casein Kinase 1 Epsilon) gene. It belongs to the Circadian category and is part of the Sleep & Circadian Rhythm biological cluster. CSNK1E encodes casein kinase 1 epsilon, which phosphorylates PER proteins to regulate their nuclear entry and circadian period.

Biological role and pathway

This variant sits within the CSNK1E gene, which is involved in the circadian clock period regulation pathway. Genes within the Sleep & Circadian Rhythm cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: CSNK1E

rs1005473 is one of 1 known variant in the CSNK1E gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1005473

Research into CSNK1E variants including rs1005473 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CSNK1E and the rs1005473 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions