rs4512021

What is the rs4512021 variant?

rs4512021 is a SNP (single nucleotide polymorphism) in the CXCL11 (C-X-C Motif Chemokine Ligand 11) gene. It belongs to the Chemokine category and is part of the Chemokines biological cluster. CXCL11 encodes an interferon-inducible chemokine that attracts CXCR3-expressing T cells with greater potency than CXCL9 or CXCL10.

Biological role and pathway

This variant sits within the CXCL11 gene, which is involved in the interferon-induced T cell recruitment pathway. Genes within the Chemokines cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: CXCL11

rs4512021 is one of 1 known variant in the CXCL11 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs4512021

Research into CXCL11 variants including rs4512021 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CXCL11 and the rs4512021 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions