rs2839693
Variant in the CXCL12 gene (C-X-C Motif Chemokine Ligand 12)
rs2839693 is a single nucleotide polymorphism (SNP) in the CXCL12 gene, involved in hematopoietic cell homing. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2839693 variant?
rs2839693 is a SNP (single nucleotide polymorphism) in the CXCL12 (C-X-C Motif Chemokine Ligand 12) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. CXCL12 (SDF-1) is the ligand for CXCR4 and CXCR7, mediating hematopoietic stem cell retention in bone marrow, lymphocyte trafficking, and tumor cell migration. It is a major regulator of immune cell homeostasis.
Biological role and pathway
This variant sits within the CXCL12 gene, which is involved in the hematopoietic cell homing pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2839693 and Long COVID / ME-CFS research
CXCL12-CXCR4 axis regulates T cell trafficking to inflamed tissues. Altered CXCL12 expression in COVID-19 affects lymphocyte distribution and persistence of lymphopenia. CXCL12 variants may influence immune cell distribution patterns relevant to Long COVID immune dysregulation.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CXCL12
rs2839693 is one of 3 known variants in the CXCL12 gene. To understand the full biological context of this variant, explore the parent gene page.
View CXCL12 gene page →Conditions studied in relation to rs2839693
Research into CXCL12 variants including rs2839693 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CXCL12 and the rs2839693 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CXCL12 gene
The following variants in CXCL12 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2839693 variant in the CXCL12 gene?
rs2839693 is a single nucleotide polymorphism (SNP) located in the CXCL12 (C-X-C Motif Chemokine Ligand 12) gene, which is involved in hematopoietic cell homing. CXCL12 (SDF-1) is the ligand for CXCR4 and CXCR7, mediating hematopoietic stem cell retention in bone marrow, lymphocyte trafficking, and tumor cell migration. It is a major regulator of immune cell homeostasis.
How may the rs2839693 variant relate to Long COVID or ME/CFS?
CXCL12-CXCR4 axis regulates T cell trafficking to inflamed tissues. Altered CXCL12 expression in COVID-19 affects lymphocyte distribution and persistence of lymphopenia. CXCL12 variants may influence immune cell distribution patterns relevant to Long COVID immune dysregulation.
Can a consumer DNA test detect the rs2839693 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2839693 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CXCL12 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29785040
- [2]Nature Reviews Immunology
- [3]Cell Stem Cell