rs2280964
Variant in the CXCR3 gene (C-X-C Motif Chemokine Receptor 3)
rs2280964 is a single nucleotide polymorphism (SNP) in the CXCR3 gene, involved in T cell trafficking. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2280964 variant?
rs2280964 is a SNP (single nucleotide polymorphism) in the CXCR3 (C-X-C Motif Chemokine Receptor 3) gene. It belongs to the Adaptive Immunity category and is part of the Adaptive Immunity biological cluster. CXCR3 is expressed on activated CD4+ and CD8+ T cells and NK cells, mediating their recruitment to inflamed tissues through CXCL9, CXCL10, and CXCL11. It is upregulated by interferon signaling.
Biological role and pathway
This variant sits within the CXCR3 gene, which is involved in the T cell trafficking pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2280964 and Long COVID / ME-CFS research
CXCR3+ T cells are recruited to inflamed tissues in COVID-19 and Long COVID. CXCR3 variants affecting T cell migration into affected tissues may influence the degree of tissue T cell infiltration driving organ-specific Long COVID pathology.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CXCR3
rs2280964 is one of 3 known variants in the CXCR3 gene. To understand the full biological context of this variant, explore the parent gene page.
View CXCR3 gene page →Conditions studied in relation to rs2280964
Research into CXCR3 variants including rs2280964 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CXCR3 and the rs2280964 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CXCR3 gene
The following variants in CXCR3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2280964 variant in the CXCR3 gene?
rs2280964 is a single nucleotide polymorphism (SNP) located in the CXCR3 (C-X-C Motif Chemokine Receptor 3) gene, which is involved in T cell trafficking. CXCR3 is expressed on activated CD4+ and CD8+ T cells and NK cells, mediating their recruitment to inflamed tissues through CXCL9, CXCL10, and CXCL11. It is upregulated by interferon signaling.
How may the rs2280964 variant relate to Long COVID or ME/CFS?
CXCR3+ T cells are recruited to inflamed tissues in COVID-19 and Long COVID. CXCR3 variants affecting T cell migration into affected tissues may influence the degree of tissue T cell infiltration driving organ-specific Long COVID pathology.
Can a consumer DNA test detect the rs2280964 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2280964 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CXCR3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 28767032
- [2]Nature Reviews Immunology
- [3]Immunity