rs2228014

What is the rs2228014 variant?

rs2228014 is a SNP (single nucleotide polymorphism) in the CXCR4 (C-X-C Motif Chemokine Receptor 4) gene. It belongs to the Chemokine category and is part of the Chemokines biological cluster. CXCR4 encodes the receptor for CXCL12/SDF-1, directing hematopoietic stem cell retention in bone marrow and immune cell migration.

Biological role and pathway

This variant sits within the CXCR4 gene, which is involved in the stem cell homing and immune trafficking pathway. Genes within the Chemokines cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: CXCR4

rs2228014 is one of 1 known variant in the CXCR4 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2228014

Research into CXCR4 variants including rs2228014 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CXCR4 and the rs2228014 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions