rs1800440
Variant in the CYP1B1 gene (Cytochrome P450 Family 1 Subfamily B Member 1)
rs1800440 is a single nucleotide polymorphism (SNP) in the CYP1B1 gene, involved in xenobiotic metabolism. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1800440 variant?
rs1800440 is a SNP (single nucleotide polymorphism) in the CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) gene. It belongs to the Metabolism category and is part of the Pharmacogenomics biological cluster. CYP1B1 metabolizes estrogens, polycyclic aromatic hydrocarbons, and other AHR-regulated substrates. It is expressed in extrahepatic tissues including adrenals, brain, and endothelium.
Biological role and pathway
This variant sits within the CYP1B1 gene, which is involved in the xenobiotic metabolism pathway. Genes within the Pharmacogenomics cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1800440 and Long COVID / ME-CFS research
CYP1B1 polymorphisms affect estrogen metabolism, which is relevant to the female predominance in Long COVID and ME/CFS. Altered estrogen catabolism through CYP1B1 variants may influence hormonal contributions to Long COVID sex differences.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CYP1B1
rs1800440 is one of 3 known variants in the CYP1B1 gene. To understand the full biological context of this variant, explore the parent gene page.
View CYP1B1 gene page →Conditions studied in relation to rs1800440
Research into CYP1B1 variants including rs1800440 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CYP1B1 and the rs1800440 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CYP1B1 gene
The following variants in CYP1B1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1800440 variant in the CYP1B1 gene?
rs1800440 is a single nucleotide polymorphism (SNP) located in the CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) gene, which is involved in xenobiotic metabolism. CYP1B1 metabolizes estrogens, polycyclic aromatic hydrocarbons, and other AHR-regulated substrates. It is expressed in extrahepatic tissues including adrenals, brain, and endothelium.
How may the rs1800440 variant relate to Long COVID or ME/CFS?
CYP1B1 polymorphisms affect estrogen metabolism, which is relevant to the female predominance in Long COVID and ME/CFS. Altered estrogen catabolism through CYP1B1 variants may influence hormonal contributions to Long COVID sex differences.
Can a consumer DNA test detect the rs1800440 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1800440 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CYP1B1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 26886982
- [2]Pharmacogenetics and Genomics
- [3]Toxicological Sciences