rs2279343

What is the rs2279343 variant?

rs2279343 is a SNP (single nucleotide polymorphism) in the CYP2B6 (Cytochrome P450 Family 2 Subfamily B Member 6) gene. It belongs to the Drug Metabolism category and is part of the Detox & Medication Sensitivity biological cluster. CYP2B6 encodes a hepatic cytochrome P450 enzyme involved in metabolizing bupropion, efavirenz, and many other drugs.

Biological role and pathway

This variant sits within the CYP2B6 gene, which is involved in the Phase I xenobiotic metabolism pathway. Genes within the Detox & Medication Sensitivity cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: CYP2B6

rs2279343 is one of 2 known variants in the CYP2B6 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2279343

Research into CYP2B6 variants including rs2279343 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CYP2B6 and the rs2279343 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the CYP2B6 gene

The following variants in CYP2B6 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions