rs4244285
Variant in the CYP2C19 gene (Cytochrome P450 Family 2 Subfamily C Member 19)
rs4244285 is a single nucleotide polymorphism (SNP) in the CYP2C19 gene, involved in drug metabolism. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4244285 variant?
rs4244285 is a SNP (single nucleotide polymorphism) in the CYP2C19 (Cytochrome P450 Family 2 Subfamily C Member 19) gene. It belongs to the Metabolism category and is part of the Pharmacogenomics biological cluster. CYP2C19 activates clopidogrel and metabolizes proton pump inhibitors, antidepressants, and antifungals. Poor metabolizers have reduced clopidogrel activation (elevated cardiovascular risk) while ultrarapid metabolizers have increased drug clearance.
Biological role and pathway
This variant sits within the CYP2C19 gene, which is involved in the drug metabolism pathway. Genes within the Pharmacogenomics cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4244285 and Long COVID / ME-CFS research
Clopidogrel antiplatelet therapy may be used for Long COVID coagulopathy. CYP2C19 metabolizer status directly affects clopidogrel bioactivation and antiplatelet efficacy, making this variant critical for personalized antiplatelet therapy in Long COVID patients.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CYP2C19
rs4244285 is one of 3 known variants in the CYP2C19 gene. To understand the full biological context of this variant, explore the parent gene page.
View CYP2C19 gene page →Conditions studied in relation to rs4244285
Research into CYP2C19 variants including rs4244285 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CYP2C19 and the rs4244285 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CYP2C19 gene
The following variants in CYP2C19 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4244285 variant in the CYP2C19 gene?
rs4244285 is a single nucleotide polymorphism (SNP) located in the CYP2C19 (Cytochrome P450 Family 2 Subfamily C Member 19) gene, which is involved in drug metabolism. CYP2C19 activates clopidogrel and metabolizes proton pump inhibitors, antidepressants, and antifungals. Poor metabolizers have reduced clopidogrel activation (elevated cardiovascular risk) while ultrarapid metabolizers have increased drug clearance.
How may the rs4244285 variant relate to Long COVID or ME/CFS?
Clopidogrel antiplatelet therapy may be used for Long COVID coagulopathy. CYP2C19 metabolizer status directly affects clopidogrel bioactivation and antiplatelet efficacy, making this variant critical for personalized antiplatelet therapy in Long COVID patients.
Can a consumer DNA test detect the rs4244285 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4244285 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CYP2C19 and its variants. This is not an exhaustive literature review.
- [1]PMID: 28439149
- [2]Clinical Pharmacology & Therapeutics
- [3]New England Journal of Medicine