rs1057910
Variant in the CYP2C9 gene (Cytochrome P450 Family 2 Subfamily C Member 9)
rs1057910 is a single nucleotide polymorphism (SNP) in the CYP2C9 gene, involved in drug metabolism. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1057910 variant?
rs1057910 is a SNP (single nucleotide polymorphism) in the CYP2C9 (Cytochrome P450 Family 2 Subfamily C Member 9) gene. It belongs to the Metabolism category and is part of the Pharmacogenomics biological cluster. CYP2C9 metabolizes warfarin, NSAIDs, phenytoin, and glipizide. The *2 and *3 alleles reduce enzymatic activity, causing higher drug exposure and increasing bleeding risk with warfarin.
Biological role and pathway
This variant sits within the CYP2C9 gene, which is involved in the drug metabolism pathway. Genes within the Pharmacogenomics cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1057910 and Long COVID / ME-CFS research
Anticoagulation is used for Long COVID coagulopathy; warfarin remains relevant in some settings. CYP2C9 *2/*3 variants are the primary determinants of warfarin dose requirement and bleeding risk, making genotyping important for anticoagulation management in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CYP2C9
rs1057910 is one of 3 known variants in the CYP2C9 gene. To understand the full biological context of this variant, explore the parent gene page.
View CYP2C9 gene page →Conditions studied in relation to rs1057910
Research into CYP2C9 variants including rs1057910 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CYP2C9 and the rs1057910 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CYP2C9 gene
The following variants in CYP2C9 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1057910 variant in the CYP2C9 gene?
rs1057910 is a single nucleotide polymorphism (SNP) located in the CYP2C9 (Cytochrome P450 Family 2 Subfamily C Member 9) gene, which is involved in drug metabolism. CYP2C9 metabolizes warfarin, NSAIDs, phenytoin, and glipizide. The *2 and *3 alleles reduce enzymatic activity, causing higher drug exposure and increasing bleeding risk with warfarin.
How may the rs1057910 variant relate to Long COVID or ME/CFS?
Anticoagulation is used for Long COVID coagulopathy; warfarin remains relevant in some settings. CYP2C9 *2/*3 variants are the primary determinants of warfarin dose requirement and bleeding risk, making genotyping important for anticoagulation management in Long COVID.
Can a consumer DNA test detect the rs1057910 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1057910 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CYP2C9 and its variants. This is not an exhaustive literature review.
- [1]PMID: 27103143
- [2]Blood
- [3]Clinical Pharmacology & Therapeutics