rs5030655
Variant in the CYP2D6 gene (Cytochrome P450 Family 2 Subfamily D Member 6)
rs5030655 is a single nucleotide polymorphism (SNP) in the CYP2D6 gene, involved in drug metabolism. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs5030655 variant?
rs5030655 is a SNP (single nucleotide polymorphism) in the CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6) gene. It belongs to the Metabolism category and is part of the Pharmacogenomics biological cluster. CYP2D6 metabolizes ~25% of all prescription drugs including opioids, antidepressants, antipsychotics, and beta-blockers. Extensive polymorphism creates four phenotypic groups: poor, intermediate, normal, and ultrarapid metabolizers.
Biological role and pathway
This variant sits within the CYP2D6 gene, which is involved in the drug metabolism pathway. Genes within the Pharmacogenomics cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs5030655 and Long COVID / ME-CFS research
CYP2D6 metabolizer status affects response to antidepressants, tricyclics, and pain medications commonly used in Long COVID symptom management. Poor metabolizers may experience drug toxicity while ultrarapid metabolizers may have treatment failures.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CYP2D6
rs5030655 is one of 4 known variants in the CYP2D6 gene. To understand the full biological context of this variant, explore the parent gene page.
View CYP2D6 gene page →Conditions studied in relation to rs5030655
Research into CYP2D6 variants including rs5030655 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CYP2D6 and the rs5030655 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CYP2D6 gene
The following variants in CYP2D6 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs5030655 variant in the CYP2D6 gene?
rs5030655 is a single nucleotide polymorphism (SNP) located in the CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6) gene, which is involved in drug metabolism. CYP2D6 metabolizes ~25% of all prescription drugs including opioids, antidepressants, antipsychotics, and beta-blockers. Extensive polymorphism creates four phenotypic groups: poor, intermediate, normal, and ultrarapid metabolizers.
How may the rs5030655 variant relate to Long COVID or ME/CFS?
CYP2D6 metabolizer status affects response to antidepressants, tricyclics, and pain medications commonly used in Long COVID symptom management. Poor metabolizers may experience drug toxicity while ultrarapid metabolizers may have treatment failures.
Can a consumer DNA test detect the rs5030655 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs5030655 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for CYP2D6 and its variants. This is not an exhaustive literature review.
- [1]PMID: 25758654
- [2]Clinical Pharmacology & Therapeutics
- [3]Nature Reviews Drug Discovery