rs10741657

What is the rs10741657 variant?

rs10741657 is a SNP (single nucleotide polymorphism) in the CYP2R1 (Cytochrome P450 Family 2 Subfamily R Member 1 (Vitamin D 25-Hydroxylase)) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. CYP2R1 is the primary hepatic enzyme that hydroxylates vitamin D3 to 25-hydroxyvitamin D, the main circulating form of vitamin D.

Biological role and pathway

This variant sits within the CYP2R1 gene, which is involved in the vitamin D activation pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: CYP2R1

rs10741657 is one of 2 known variants in the CYP2R1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs10741657

Research into CYP2R1 variants including rs10741657 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CYP2R1 and the rs10741657 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the CYP2R1 gene

The following variants in CYP2R1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions